The Incidence Of Prostate Cancer Higher In Men With Autoimmune Diseases PDF Print E-mail
Monday, 06 May 2013 22:05
Men with autoimmune diseases have a higher incidence of prostate cancer (PCa) than those without those diseases, according to study findings presented at the American Urological Association annual meeting.

Using the National Inpatient Sample database, researchers obtained data on 189,290 men with a history of autoimmune disease—multiple sclerosis (MS), systemic lupus erythematosus (SLE), systemic sclerosis, psoriasis, Sjogren's syndrome, discoid lupus erythematosus (DLE), or rheumatoid arthritis (RA)—and a subsequent diagnosis of PCa.

The investigators, led by Zachary Klaassen, MD, a urology resident at the Medical College of Georgia, Georgia Regents University, in Augusta, compared the age-specific incidence of PCa in this cohort with an external cohort of patients from the Surveillance, Epidemiology and End Results (SEER) database (2000-2009).

Compared with the general population, the incidence of PCa was three times greater for men with MS, five times greater for men with SLE, six times greater for men with systemic sclerosis, seven times greater for men with psoriasis, nine times greater for men with Sjogren's syndrome, 10 times greater for men with DLE, and 10 times greater for men with RA, according to the researchers.
Autoimmune disease affects 3.6 million to 5.9 million men in the U.S., Dr. Klaassen and his colleagues noted.

To their knowledge, the investigators said, their study is the first to suggest an increased incidence of PCa in men with autoimmune diseases.

Dr. Klaassen cautioned that the finding of an increased incidence of PCa may be due to increased screening of patients who, because of their autoimmune disease, may receive more intensive medical follow-up.

Source: Renal & Urology News (2013), "Prostate Cancer Incidence Higher in Men with Autoimmune Disease"; original article can be viewed here.

 
More articles :

» What Causes Scleroderma?

Collagen is a group of naturally occurring proteins, found exclusively in animals and especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, constituting...

» Finding Reliable Health Information Online

As Internet users quickly discover, an enormous amount of health information is available online. Finding accurate and reliable information on genetic and rare diseases among the millions of online sources is a difficult task for almost everyone. We...

» Simple Predictor In Scleroderma Related Interstitial Lung Disease

Patients at high risk of deterioration or death from Systemic Sclerosis-related interstitial lung disease can be readily spotted using CT scans, suggest Melbourne researchers.Patients classified as having “extensive” (> 20%) lung disease as...

» Therapies for Scleroderma-related Pulmonary Arterial Hypertension

Paul M. HassounPosted: 08/20/2009; Expert Rev Resp Med. 2009;3(2):187-196. © 2009 Expert Reviews Ltd.Pulmonary arterial hypertension (PAH), a common complication of systemic sclerosis, carries a very severe prognosis and is one of the leading...

» Gene Profiling of Scleroderma Skin Reveals Robust Signatures of Disease...

Humphrey Gardner, Jeffrey R. Shearstone, Raj Bandaru, Tom Crowell, Matthew Lynes, Maria Trojanowska, Jaspreet Pannu, Edwin Smith, Stefania Jablonska, Maria Blaszczyk, Filemon K. Tan, and Maureen D. MayesARTHRITIS & RHEUMATISMVol. 54, No. 6, June...

» Endothelin Receptor Antagonists for the Treatment of Raynaud’s Phenomenon and Digital Ulcers in Systemic Sclerosis

Kait Arefiev, David F. Fiorentino, and Lorinda ChungDivision of Immunology and Rheumatology, Departments of Dermatology and Medicine, Stanford University School of Medicine, Palo Alto VA Health Care System, 3801 Miranda Avenue, Palo Alto, CA 94304,...